Issue 12, 2015

The coaction of tonic and phasic dopamine dynamics

Abstract

Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 × 10−6 cm2 s−1) in the mouse brain.

Graphical abstract: The coaction of tonic and phasic dopamine dynamics

Supplementary files

Article information

Article type
Communication
Submitted
11 Aug 2014
Accepted
15 Sep 2014
First published
24 Sep 2014

Chem. Commun., 2015,51, 2235-2238

Author version available

The coaction of tonic and phasic dopamine dynamics

C. W. Atcherley, K. M. Wood, K. L. Parent, P. Hashemi and M. L. Heien, Chem. Commun., 2015, 51, 2235 DOI: 10.1039/C4CC06165A

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