Issue 1, 2002
From the journal:

Natural Product Reports

From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase

Alexey Teplyakov,a   Caroline Leriche,b   Galya Obmolova,a   Bernard Badet*c  and  Marie-Ange Badet-Denisotc  

* Corresponding authors

a Center for Advanced Research in Biotechnology, University of Maryland, 9600 Gudelsky Drive, Rockville, U.S.A.

b Department of Medicinal Chemistry, Merck, 4 avenue du Président F. Mitterrand, Chilly-Mazarin, France

c Institut de Chimie des Substances Naturelles-CNRS, Gif-sur-Yvette Cedex, France
E-mail: badet@icsn.cnrs-gif.fr

Abstract

Covering: up to June 2001

This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes.

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Article information

DOI
https://doi.org/10.1039/B103713G
Article type
Review Article
Submitted
24 Sep 2001
First published
07 Nov 2001

Nat. Prod. Rep., 2002,19, 60-69

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From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase

A. Teplyakov, C. Leriche, G. Obmolova, B. Badet and M. Badet-Denisot, Nat. Prod. Rep., 2002, 19, 60 DOI: 10.1039/B103713G

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