Issue 40, 2013
From the journal:

Chemical Communications

The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

Hong Zhao,†a   Jarrod B. French,†a   Ye Fangb  and  Stephen J. Benkovic*a  

* Corresponding authors

a Department of Chemistry, The Pennsylvania State University, 414 Wartik Laboratory, University Park, PA, USA
E-mail: sjb1@psu.edu
Fax: +1 814-865-2973
Tel: +1 814-865-2882

b Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY, USA

Abstract

Purine nucleotides are ubiquitous molecules that play vital roles in all kingdoms of life, not only as components of nucleic acids, but also participating in signaling and energy storage. Cellular pools of purines are maintained by the tight control of several complementary and sometimes competing processes including de novo biosynthesis, salvage and catabolism of nucleotides. While great strides have been made over the past sixty years in understanding the biosynthesis of purines, we are experiencing a renaissance in this field. In this feature article we discuss the most recent discoveries relating to purine biosynthesis, with particular emphasis upon the dynamic multi-protein complex called the purinosome. In particular we highlight advances made towards understanding the assembly, control and function of this protein complex and the attempts made to exploit this knowledge for drug discovery.

Graphical abstract: The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

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Article information

DOI
https://doi.org/10.1039/C3CC41437J
Article type
Feature Article
Submitted
25 Feb 2013
Accepted
02 Apr 2013
First published
03 Apr 2013

Chem. Commun., 2013,49, 4444-4452

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The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

H. Zhao, J. B. French, Y. Fang and S. J. Benkovic, Chem. Commun., 2013, 49, 4444 DOI: 10.1039/C3CC41437J

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