Issue 75, 2013

Light-inducible activation of target mRNA translation in mammalian cells

Abstract

A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.

Graphical abstract: Light-inducible activation of target mRNA translation in mammalian cells

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2013
Accepted
17 Jul 2013
First published
08 Aug 2013

Chem. Commun., 2013,49, 8338-8340

Light-inducible activation of target mRNA translation in mammalian cells

J. Cao, M. Arha, C. Sudrik, L. J. Bugaj, D. V. Schaffer and R. S. Kane, Chem. Commun., 2013, 49, 8338 DOI: 10.1039/C3CC44866E

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