Issue 40, 2014
From the journal:

Chemical Communications

A molecular rotor for measuring viscosity in plasma membranes of live cells†

Ismael López-Duarte,‡a   Thanh Truc Vu,‡a   M. Angeles Izquierdo,a   James A. Bulla  and  Marina K. Kuimova*a  

* Corresponding authors

a Chemistry Department, Imperial College London, Exhibition Road, South Kensington, UK
E-mail: m.kuimova@imperial.ac.uk

Abstract

Molecular rotors have emerged as versatile probes for microscopic viscosity in live cells, however, the exclusive localisation of rotors in the plasma membrane has remained elusive. We report the synthesis, spectroscopic characterisation and live cell imaging of a new BODIPY-based molecular rotor suitable for mapping viscosity in the cell plasma membrane.

Graphical abstract: A molecular rotor for measuring viscosity in plasma membranes of live cells

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Article information

DOI
https://doi.org/10.1039/C3CC47530A
Article type
Communication
Submitted
01 Oct 2013
Accepted
06 Nov 2013
First published
07 Nov 2013

Chem. Commun., 2014,50, 5282-5284

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A molecular rotor for measuring viscosity in plasma membranes of live cells

I. López-Duarte, T. T. Vu, M. A. Izquierdo, J. A. Bull and M. K. Kuimova, Chem. Commun., 2014, 50, 5282 DOI: 10.1039/C3CC47530A

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