Issue 3, 2014
From the journal:

Soft Matter

Structural and dynamical properties of reconstituted myelin sheaths in the presence of myelin proteins MBP and P2 studied by neutron scattering†

Wiebke Knoll,ab   Judith Peters,abc   Petri Kursula,de   Yuri Gerelli,b   Jacques Ollivier,b   Bruno Demé,b   Mark Telling,fg   Ewout Kemnerh  and  Francesca Natali*bi  

* Corresponding authors

a University Joseph Fourier UFR PhITEM, Grenoble, France

b Institut Laue–Langevin, Grenoble, France
E-mail: natali@ill.fr

c Institut de Biologie Structurale, Grenoble, France

d Department of Biochemistry & Biocenter Oulu, University of Oulu, Oulu, Finland

e Department of Chemistry, , University of Hamburg & CSSB-HZI/DESY, Hamburg, Germany

f ISIS Facility, Rutherford Appleton Laboratory, Didcot, UK

g Department of Materials, University of Oxford, Oxford, UK

h Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Berlin, Germany

i CNR–IOM–OGG, c/o Institut Laue–Langevin, Grenoble, France

Abstract

The myelin sheath is a tightly packed, multilayered membrane structure wrapped around selected nerve axons in the central and the peripheral nervous system. Because of its electrical insulation of the axons, which allows fast, saltatory nerve impulse conduction, myelin is crucial for the proper functioning of the vertebrate nervous system. A subset of myelin-specific proteins is well-defined, but their influence on membrane dynamics, i.e. myelin stability, has not yet been explored in detail. We investigated the structure and the dynamics of reconstituted myelin membranes on a pico- to nanosecond timescale, influenced by myelin basic protein (MBP) and myelin protein 2 (P2), using neutron diffraction and quasi-elastic neutron scattering. A model for the scattering function describing molecular lipid motions is suggested. Although dynamical properties are not affected significantly by MBP and P2 proteins, they act in a highly synergistic manner influencing the membrane structure.

Graphical abstract: Structural and dynamical properties of reconstituted myelin sheaths in the presence of myelin proteins MBP and P2 studied by neutron scattering

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Article information

DOI
https://doi.org/10.1039/C3SM51393A
Article type
Paper
Submitted
18 May 2013
Accepted
04 Nov 2013
First published
05 Nov 2013

Soft Matter, 2014,10, 519-529

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Structural and dynamical properties of reconstituted myelin sheaths in the presence of myelin proteins MBP and P2 studied by neutron scattering

W. Knoll, J. Peters, P. Kursula, Y. Gerelli, J. Ollivier, B. Demé, M. Telling, E. Kemner and F. Natali, Soft Matter, 2014, 10, 519 DOI: 10.1039/C3SM51393A

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