Abstract
DNA sequence variation between JCV genotypes is confined largely to noncoding intergenic regions and introns. Nevertheless, evidence suggests that the amino acid sequence variations among the 8 genotypes of JCV can influence the potential for neurovirulence of the virus. In the current study, the amino acid sequences for 100 JCV genomes were translated and grouped into genotype families. Subtype consensus sequences were determined and the type-specific amino acid sequence variants were identified.
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Agostini HT, Deckhut AM, Jobes DV, Girones R, Schlunck G, Prost MG, Frias C, Pérez-Trallero E, Ryschkewitsch CF, Stoner GL (2001). Genotypes of JC virus in East, Central and Southwest Europe. J Gen Virol 82: 1221–1231.
Agostini HT, Jobes DV, Chima SC, Ryschkewitsch CF, Stoner GL (1999). Natural and pathogenic variation in the JC virus genome. In: Recent Research Development in Virology. Pandalai SG (ed). Trivandrum, India: Transworld Research Network, pp 683–701.
Agostini HT, Ryschkewitsch CF, Baumhefner RW, Tourtellotte WW, Singer EJ, Komoly S, Stoner GL (2000). Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy. J NeuroVirol 6(Suppl 2): S101-S108.
Agostini HT, Ryschkewitsch CF, Stoner GL (1998). Complete genome of a JC virus genotype Type 6 from the brain of an African American with progressive multifocal leukoencephalopathy. J Hum Virol 1: 267–272.
Chima SC, Ryschkewitsch CF, Fan KJ, Stoner GL (2000). Polyomavirus JC genotypes in an urban United States population reflect the history of African origin and genetic admixture in modern African Americans. Hum Riol 72: 837–850.
Chimelli L, Rosemberg S, Hahn MD, Lopes MBS, Barretto Netto M (1992). Pathology of the central nervous system in patients infected with the human immunodeficiency virus (HIV): A report of 252 autopsy cases from Brazil. Neuropathol Appl Neurobiol 18: 478–488.
Dubois V, Moret H, Lafon ME, Brodard V, Icart J, Ruffault A, Guist’hau O, Buffet-Janvresse C, Abbed K, Dussaix E, Ingrand D (2001). JC virus genotypes in France: Molecular epidemiology and potential significance for progressive multifocal leukoencephalopathy. J Infect Dis 183: 213–217.
Jobes DV, Chima SC, Ryschkewitsch CF, Stoner GL (1998). Phylogenetic analysis of 22 complete genomes of the human polyomavirus JC virus. J Gen Virol 79: 2491–2498.
Jobes DV, Friedlaender JS, Mgone CS, Koki G, Alpers MP, Ryschkewitsch CF, Stoner GL (1999). A novel JC virus variant found in the Highlands of Papua New Guinea has a 21-base pair deletion in the agnoprotein gene. J Hum Virol 2: 350–358.
Kuchelmeister K, Gullotta F, Bergman M, Angeli G, Masini T (1993). Progressive multifocal leukoencephalopathy (PML) in the acquired immunodeficiency syndrome (AIDS). A neuropathological study of 21 cases. Pathol Res Pract 189: 163–173.
Stoner GL, Jobes DV, Fernandez Cobo M, Agostini HT, Chima SC, Ryschkewitsch CF (2000). JC virus as a marker of human migration to the Americas. Microbe Infect 2: 1905–1911.
Stoner GL, Ryschkewitsch CF (1995). Capsid protein VP1 deletions in JC virus from two AIDS patients with progressive multifocal leukoencephalopathy. J NeuroVirol 1: 189–194.
Sugimoto C, Kitamura T, Guo J, Al-Ahdal MN, Shchelkunov SN, Otova B, Ondrejka P, Chollet JY, El-Safi S, Ettayebi M, Grésenguet G, Kocagöz T, Chaiyarasamee S, Thant KZ, Thein S, Moe K, Kobayashi N, Taguchi F, Yogo Y (1997). Typing of urinary JC virus DNA offers a novel means of tracing human migrations. Proc Natl Acad Sci USA 94: 9191–9196.
Trowbridge PW, Frisque RJ (1995). Identification of three new JC virus proteins generated by alternative splicing of the early viral mRNA. J NeuroVirol 1: 195–206.
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Cubitt, C.L., Cui, X., Agostini, H.T. et al. Predicted amino acid sequences for 100 JCV strains. Journal of NeuroVirology 7, 339–344 (2001). https://doi.org/10.1080/13550280152537201
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DOI: https://doi.org/10.1080/13550280152537201