1887

Abstract

Previous studies have identified several host-derived cell-surface proteins incorporated within emerging human immunodeficiency virus type 1 (HIV-1) particles. Some of these molecules play a role in different steps of the virus life cycle and are often advantageous for the virus. We report here that the leukocyte L-selectin (also called CD62L) remains functional when inserted within the envelope of HIV-1. Indeed, we demonstrate that adsorption of virions to endothelial cells is enhanced upon acquisition of host-derived CD62L. The more important binding of CD62L-bearing HIV-1 particles resulted in a more efficient virus transmission to CD4 T lymphocytes. Capture and eventual transfer of such CD62L-bearing virions by the endothelium could play a role in the pathogenesis of HIV-1 infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.83032-0
2007-09-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/88/9/2568.html?itemId=/content/journal/jgv/10.1099/vir.0.83032-0&mimeType=html&fmt=ahah

References

  1. Abbate I., Dianzani F., Bianchi F., Mosiello G., Carletti F., Fiumara D., Capobianchi M. R. 1999; RANTES stimulates cell-mediated transmission of HIV-1 infection. J Interferon Cytokine Res 19:345–350 [CrossRef]
    [Google Scholar]
  2. Alvarez C. P., Lasala F., Carrillo J., Muniz O., Corbi A. L., Delgado R. 2002; C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans . J Virol 76:6841–6844 [CrossRef]
    [Google Scholar]
  3. Arias R. A., Munoz L. D., Munoz-Fernandez M. A. 2003; Transmission of HIV-1 infection between trophoblast placental cells and T-cells take place via an LFA-1-mediated cell to cell contact. Virology 307:266–277 [CrossRef]
    [Google Scholar]
  4. Bashirova A. A., Geijtenbeek T. B., van Duijnhoven G. C., van Vliet S. J., Eilering J. B., Martin M. P., Wu L., Martin T. D., Viebig N. other authors 2001; A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J Exp Med 193:671–678 [CrossRef]
    [Google Scholar]
  5. Bastiani L., Laal S., Kim M., Zolla-Pazner S. 1997; Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions. J Virol 71:3444–3450
    [Google Scholar]
  6. Bobardt M. D., Saphire A. C., Hung H. C., Yu X., Van der Schueren B., Zhang Z., David G., Gallay P. A. 2003; Syndecan captures, protects, and transmits HIV to T lymphocytes. Immunity 18:27–39 [CrossRef]
    [Google Scholar]
  7. Bounou S., Leclerc J. E., Tremblay M. J. 2002; Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4+-T-cell depletion in human lymphoid tissue, a major site of replication in vivo. J Virol 76:1004–1014 [CrossRef]
    [Google Scholar]
  8. Bounou S., Giguère J. F., Cantin R., Gilbert C., Imbeault M., Martin G., Tremblay M. J. 2004; The importance of virus-associated host ICAM-1 in human immunodeficiency virus type 1 dissemination depends on the cellular context. FASEB J 18:1294–1296
    [Google Scholar]
  9. Cantin R., Fortin J.-F., Lamontagne G., Tremblay M. 1997; The acquisition of host-derived major histocompatibility complex class II glycoproteins by human immunodeficiency virus type 1 accelerates the process of virus entry and infection in human T-lymphoid cells. Blood 90:1091–1100
    [Google Scholar]
  10. Cantin R., Méthot S., Tremblay M. J. 2005; Plunder and stowaways: incorporation of cellular proteins by enveloped viruses. J Virol 79:6577–6587 [CrossRef]
    [Google Scholar]
  11. Castilletti C., Capobianchi M. R., Fais S., Abbate I., Ficociello B., Ameglio F., Cordiali Fei P., Santini S. M., Dianzani F. 1995; HIV type 1 grown on interferon gamma-treated U937 cells shows selective increase in virion-associated intercellular adhesion molecule 1 and HLA-DR and enhanced infectivity for CD4-negative cells. AIDS Res Hum Retroviruses 11:547–553 [CrossRef]
    [Google Scholar]
  12. Clapham P. R., McKnight A. 2001; HIV-1 receptors and cell tropism. Br Med Bull 58:43–59 [CrossRef]
    [Google Scholar]
  13. Dakappagari N., Maruyama T., Renshaw M., Tacken P., Figdor C., Torensma R., Wild M. A., Wu D., Bowdish K., Kretz-Rommel A. 2006; Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses. J Immunol 176:426–440 [CrossRef]
    [Google Scholar]
  14. De Milito A. 2004; B lymphocyte dysfunctions in HIV infection. Curr HIV Res 2:11–21 [CrossRef]
    [Google Scholar]
  15. Decrion A. Z., Dichamp I., Varin A., Herbein G. 2005; HIV and inflammation. Curr HIV Res 3:243–259 [CrossRef]
    [Google Scholar]
  16. Fortin J.-F., Cantin R., Lamontagne G., Tremblay M. 1997; Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity. J Virol 71:3588–3596
    [Google Scholar]
  17. Geijtenbeek T. B., Kwon D. S., Torensma R., van Vliet S. J., van Duijnhoven G. C., Middel J., Cornelissen I. L., Nottet H. S., KewalRamani V. N. other authors 2000; DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans -infection of T cells. Cell 100:587–597 [CrossRef]
    [Google Scholar]
  18. Giguère J.-F., Diou J., Madrenas J., Tremblay M. J. 2005; Virus attachment and replication are promoted after acquisition of host CD28 and CD152 by HIV-1. J Infect Dis 192:1265–1268 [CrossRef]
    [Google Scholar]
  19. Halary F., Amara A., Lortat-Jacob H., Messerle M., Delaunay T., Houles C., Fieschi F., Arenzana-Seisdedos F., Moreau J. F., Dechanet-Merville J. 2002; Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans -infection. Immunity 17:653–664 [CrossRef]
    [Google Scholar]
  20. Herrmann J. L., Lagrange P. H. 2005; Dendritic cells and Mycobacterium tuberculosis : which is the Trojan horse?. Pathol Biol (Paris) 53:35–40 [CrossRef]
    [Google Scholar]
  21. Kolegraff K., Bostik P., Ansari A. A. 2006; Characterization and role of lentivirus-associated host proteins. Exp Biol Med (Maywood) 231:252–263
    [Google Scholar]
  22. Martin G., Tremblay M. J. 2004; HLA-DR, ICAM-1, CD40, CD40L, and CD86 are incorporated to a similar degree into clinical human immunodeficiency virus type 1 variants expanded in natural reservoirs such as peripheral blood mononuclear cells and human lymphoid tissue cultured ex vivo. Clin Immunol 111:275–285 [CrossRef]
    [Google Scholar]
  23. McEver R. P., Cummings R. D. 1997; Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest 100:S97–S103
    [Google Scholar]
  24. Norgard-Sumnicht K., Varki A. 1995; Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groups. J Biol Chem 270:12012–12024 [CrossRef]
    [Google Scholar]
  25. Ott D. E. 1997; Cellular proteins in HIV virions. Rev Med Virol 7:167–180 [CrossRef]
    [Google Scholar]
  26. Ott D. E. 2002; Potential roles of cellular proteins in HIV-1. Rev Med Virol 12:359–374 [CrossRef]
    [Google Scholar]
  27. Pablos J. L., Santiago B., Tsay D., Singer M. S., Palao G., Galindo M., Rosen S. D. 2005; A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin- α / β and TNF- α in cultured endothelial cells. BMC Immunol 6:6 [CrossRef]
    [Google Scholar]
  28. Paquette J.-S., Fortin J.-F., Blanchard L., Tremblay M. J. 1998; Level of ICAM-1 surface expression on virus producer cells influences both the amount of virion-bound host ICAM-1 and human immunodeficiency virus type 1 infectivity. J Virol 72:9329–9336
    [Google Scholar]
  29. Pierson T. C., Doms R. W. 2003; HIV-1 entry and its inhibition. Curr Top Microbiol Immunol 281:1–27
    [Google Scholar]
  30. Piguet V., Sattentau Q. 2004; Dangerous liaisons at the virological synapse. J Clin Invest 114:605–610 [CrossRef]
    [Google Scholar]
  31. Rosen S. D. 2004; Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol 22:129–156 [CrossRef]
    [Google Scholar]
  32. Sassetti C., Tangemann K., Singer M. S., Kershaw D. B., Rosen S. D. 1998; Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. J Exp Med 187:1965–1975 [CrossRef]
    [Google Scholar]
  33. Tedder T. F., Isaacs C. M., Ernst T. J., Demetri G. D., Adler D. A., Disteche C. M. 1989; Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. J Exp Med 170:123–133 [CrossRef]
    [Google Scholar]
  34. Tu L., Delahunty M. D., Ding H., Luscinskas F. W., Tedder T. F. 1999; The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. J Exp Med 189:241–252 [CrossRef]
    [Google Scholar]
  35. Turville S. G., Cameron P. U., Handley A., Lin G., Pohlmann S., Doms R. W., Cunningham A. L. 2002; Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol 3:975–983 [CrossRef]
    [Google Scholar]
  36. Turville S., Wilkinson J., Cameron P., Dable J., Cunningham A. L. 2003; The role of dendritic cell C-type lectin receptors in HIV pathogenesis. J Leukoc Biol 74:710–718 [CrossRef]
    [Google Scholar]
  37. Turville S. G., Santos J. J., Frank I., Cameron P. U., Wilkinson J., Miranda-Saksena M., Dable J., Stossel H., Romani N. other authors 2004; Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells. Blood 103:2170–2179 [CrossRef]
    [Google Scholar]
  38. Zhao C., Cantin R., Breton M., Papadopoulou B., Tremblay M. J. 2005; DC-SIGN-mediated transfer of HIV-1 is compromised by the ability of Leishmania infantum to exploit DC-SIGN as a ligand. J Infect Dis 191:1665–1669 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.83032-0
Loading
/content/journal/jgv/10.1099/vir.0.83032-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error