Abstract
We compare and synthesize the results of two microrheological experiments on the cytoskeleton of single cells. In the first one, the creep function of a cell stretched between two glass plates is measured after applying a constant force step. In the second one, a microbead specifically bound to transmembrane receptors is driven by an oscillating optical trap, and the viscoelastic coefficient is retrieved. Both and exhibit power law behaviors: and , with the same exponent . This power law behavior is very robust; is distributed over a narrow range, and shows almost no dependence on the cell type, on the nature of the protein complex which transmits the mechanical stress, nor on the typical length scale of the experiment. On the contrary, the prefactors and appear very sensitive to these parameters. Whereas the exponents are normally distributed over the cell population, the prefactors and follow a log-normal repartition. These results are compared with other data published in the literature. We propose a global interpretation, based on a semiphenomenological model, which involves a broad distribution of relaxation times in the system. The model predicts the power law behavior and the statistical repartition of the mechanical parameters, as experimentally observed for the cells. Moreover, it leads to an estimate of the largest response time in the cytoskeletal network: .
7 More- Received 24 March 2006
DOI:https://doi.org/10.1103/PhysRevE.74.021911
©2006 American Physical Society