Thermodynamic Fluctuations in a Reacting System—Measurement by Fluorescence Correlation Spectroscopy

Douglas Magde, Elliot Elson, and W. W. Webb
Phys. Rev. Lett. 29, 705 – Published 11 September 1972
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Abstract

The temporal correlations of thermodynamic concentration fluctuations have been measured in a chemically reactive system at equilibrium by observing fluctuations of the fluorescence of a reaction product. The experiment yields the chemical rate constants and diffusion coefficients and shows the coupling among them. Data are reported for binding of ethidium bromide to DNA.

  • Received 10 July 1972

DOI:https://doi.org/10.1103/PhysRevLett.29.705

©1972 American Physical Society

Authors & Affiliations

Douglas Magde*, Elliot Elson, and W. W. Webb

  • Cornell University, Ithaca, New York 14850

  • *Now at Department of Chemistry, Washington State University, Pullman, Wash. 99163.
  • Department of Chemistry.
  • School of Applied and Engineering Physics and Laboratory for Atomic and Solid State Physics.

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Vol. 29, Iss. 11 — 11 September 1972

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