ORIGINAL ARTICLEBack signaling of HLA class I molecules and T/NK cell receptor ligands in epithelial cells reflects the rejection-specific microenvironment in renal allograft biopsies
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KEYWORDS
basic (laboratory) research/science
biomarker
immune regulation
immunobiology
immunosuppression/immune modulation
kidney transplantation/nephrology
natural killer (NK) cells/NK receptors
rejection: antibody-mediated (ABMR)
T cell biology
Abbreviations
ABMR
antibody-mediated rejection
ALCAM
activated leukocyte cell adhesion molecule
BSA
bovine serum albumin
CCL
CC-motif chemokine ligand
CD
cluster of differentiation
CNI
calcineurin inhibitor
CsA
cyclosporine A
CXCL
CXC-motif chemokine ligand
DMSO
dimethylsulfoxide
DNAM
DNAX accessory molecule
DSA
donor-specific anti-HLA antibodies
EC
endothelial cell
Eve
everolimus
FBS
fetal bovine serum
HLA
human leukocyte antigen
ICAM
intercellular adhesion molecule
IFN
interferon
IKK
IκB kinase
IL
interleukin
ISD
immunosuppressive drugs
JNK
c-jun kinase
KTx
kidney transplantation
LPS
lipopolysaccharide
mAb(s)
monoclonal antibody(ies)
MAPK
mitogen-activated protein kinase
MFI
median fluorescence intensity
MHH
Hannover Medical School
mTORi
mammalian target of rapamycin inhibitor
n.s.
not significant
NFκB
nuclear factor κB
NKcell
natural killer cell
p70S6K
p70 S6 kinase
PBMC
peripheral blood mononuclear cell
PBS
phosphate-buffered saline
PHA
phytohemagglutinin
PI3K
phosphatidylinositol-3-kinase
PMA
phorbol-12-myristat-13-acetat
PTEC
proximal tubular epithelial cell
PTEN
phosphatase and tensin homolog
RPS6
ribosomal protein S6
RT-PCR
real-time polymerase chain reaction
Sir
sirolimus
Sora
sorafenib
Tac
tacrolimus
TCMR
T cell-mediated rejection
TNF
tumor necrosis factor
VCAM
vascular cell adhesion molecule
Cited by (0)
See also: Valenzuela
Copyright © 2019 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.