ORIGINAL ARTICLEMaintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2
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Cited by (38)
Analysis of the novel excretory cell expressed ECP-1 protein and its proposed ECP-1/IFC-2 fusion protein EXC-2 in the nematode Caenorhabditis elegans
2019, Gene Expression PatternsCitation Excerpt :Moreover, existence of the latter exc-2 fusion mRNA would be supported also by a) the similar RNAi phenotypes, induced possibly through targeting of this large ecp-1/ifc-2 fusion exc-2 transcript by both the ecp-1 and the ifc-2 dsRNA b) the single EST sequence containing both the ECP-1 and the IFC-2 specific exons (Fig. 1A and text above) as well as c) by the study of Al-Hashimi et al. which documented expression of the tagged EXC-2 fusion proteins by multiple genetic methods. However, it should be noted in this respect that the abundance of the large EXC-2 fusion protein in the excretory cells or in the intestine might be rather weak since a) the immunofluorescence experiments using the ECP-1-specific antibody, described above, failed to stain the intestine in worms (Table 1, Fig. 2) and reciprocally b) the immunofluorescence experiments using the IFC-2-specific antibody, described above, failed to stain the excretory tissue in worms (Table 1, Fig. 2; see also Karabinos et al., 2002; Hüsken et al., 2008). Development of the excretory system in C. elegans needs interactions between extracellular matrix, cell surfaces and the cytoskeleton (Francis and Waterston, 1991; Chin-Sang and Chisholm, 2000; Hahn and Labouesse, 2001; Kolotuev et al., 2013).
Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs
2019, GeneCitation Excerpt :Orthologs of the vertebrate cytoplasmic type I to III IF proteins have also been found in early chordates (Karabinos, 2013 and references therein). The primary (but not sole) function of the cytoplasmic IF cytoskeleton is to provide mechanical resistance, as revealed by a variety of mutated keratin-induced diseases (Irvine and McLean, 1999), by knock-out mice (i.e. Hesse et al., 2000; Vijayaraj et al., 2009) or by (reverse) genetics in the nematode C. elegans (Karabinos et al., 2001, 2003a, 2004; Hapiak et al., 2003; Woo et al., 2004; Hüsken et al., 2008; Zhang et al., 2011). The nematode C. elegans has a single and essential nuclear lamin gene lmn-1 (Liu et al., 2000; Fraser et al., 2000), and eleven cytoplasmic IF genes, some of which give rise to alternative splice variants (Dodemont et al., 1994; Karabinos et al., 2001; Woo et al., 2004).
Transorganogenesis and transdifferentiation in C. elegans are dependent on differentiated cell identity
2016, Developmental BiologyCitation Excerpt :Thus, ELT-7 is not uniquely capable of reprogramming differentiated cells and in contrast to earlier reports (Fukushige et al., 1998; Djabrayan et al., 2012) the capacity of transcription factors to override the MCT and reprogram even fully differentiated post-mitotic cells is distributed among most of the endoderm regulatory factors. To investigate the dynamics of pharynx remodeling following ectopic ELT-7 expression at each C. elegans larval stage (L1-L4), we analyzed expression of CFP-tagged intermediate filament protein, IFB-2 (Husken et al., 2008). IFB-2 is a component of the terminal web structure that localizes specifically to the apical surface of intestinal cells and is never detected outside of the intestine (Fig. 2B; Fukushige and McGhee, 2001; Maduro and Rothman, 2002; Husken et al., 2008).
Mechanical Probing of the Intermediate Filament-Rich Caenorhabditis Elegans Intestine
2016, Methods in EnzymologyA rod domain sequence in segment 1B triggers dimerisation of the two small Branchiostoma IF proteins B2 and A3
2012, European Journal of Cell Biology