Macrophages and the Regulation of Adipose Tissue Remodeling

Literature Cited

1. Alexander CM, Selvarajan S, Mudgett J, Werb Z. 1.  2001. Stromelysin-1 regulates adipogenesis during mammary gland involution. J. Cell Biol. 152:693–703 [Google Scholar]
2. Altintas MM, Azad A, Nayer B, Contreras G, Zaias J. 2.  et al. 2011. Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice. J. Lipid Res. 52:480–88 [Google Scholar]
3. Arner E, Westermark PO, Spalding KL, Britton T, Ryden M. 3.  et al. 2010. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59:105–9 [Google Scholar]
4. Arner P, Bernard S, Salehpour M, Possnert G, Liebl J. 4.  et al. 2011. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478:110–13 [Google Scholar]
5. Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D. 5.  et al. 2009. Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J. Clin. Endocrinol. Metab. 94:4619–23 [Google Scholar]
6. Barbarroja N, López-Pedrera R, Mayas MD, Garcia-Fuentes E, Garrido-Sánchez L. 6.  et al. 2010. The obese healthy paradox: Is inflammation the answer?. Biochem. J. 430:141–49 [Google Scholar]
7. Bernot D, Barruet E, Poggi M, Bonardo B, Alessi MC, Peiretti F. 7.  2010. Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation. J. Biol. Chem. 285:6508–14 [Google Scholar]
8. Berry R, Rodeheffer MS. 8.  2013. Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Biol. 15:302–8 [Google Scholar]
9. Bigornia SJ, Farb MG, Mott MM, Hess DT, Carmine B. 9.  et al. 2012. Relation of depot-specific adipose inflammation to insulin resistance in human obesity. Nutr. Diabetes 2:e30 [Google Scholar]
10. Bilkovski R, Schulte DM, Oberhauser F, Mauer J, Hampel B. 10.  et al. 2011. Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt-5a in humans. Int. J. Obes. (Lond.) 35:1450–54 [Google Scholar]
11. Bluher M. 11.  2010. The distinction of metabolically “healthy” from “unhealthy” obese individuals. Curr. Opin. Lipidol. 21:38–43 [Google Scholar]
12. Bourlier V, Sengenes C, Zakaroff-Girard A, Decaunes P, Wdziekonski B. 12.  et al. 2012. TGFβ family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages. PLoS ONE 7:e31274 [Google Scholar]
13. Bourlier V, Zakaroff-Girard A, Miranville A, De Barros S, Maumus M. 13.  et al. 2008. Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation 117:806–15 [Google Scholar]
14. Bradshaw AD, Graves DC, Motamed K, Sage EH. 14.  2003. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc. Natl. Acad. Sci. USA 100:6045–50 [Google Scholar]
15. Bradshaw AD, Sage EH. 15.  2001. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J. Clin. Invest. 107:1049–54 [Google Scholar]
16. Carreau A, El Hafny-Rahbi B, Matejuk A, Grillon C, Kieda C. 16.  2011. Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J. Cell Mol. Med. 15:1239–53 [Google Scholar]
17. Cawthorn WP, Scheller EL, MacDougald OA. 17.  2012. Adipose tissue stem cells: the great WAT hope. Trends Endocrinol. Metab. 23:270–77 [Google Scholar]
18. Chandler EM, Berglund CM, Lee JS, Polacheck WJ, Gleghorn JP. 18.  et al. 2011. Stiffness of photocrosslinked RGD-alginate gels regulates adipose progenitor cell behavior. Biotechnol. Bioeng. 108:1683–92 [Google Scholar]
19. Chavey C, Boucher J, Monthouel-Kartmann MN, Sage EH, Castan-Laurell I. 19.  et al. 2006. Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia. Obesity(Silver Spring) 14:1890–97 [Google Scholar]
20. Chavey C, Mari B, Monthouel MN, Bonnafous S, Anglard P. 20.  et al. 2003. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J. Biol. Chem. 278:11888–96 [Google Scholar]
21. Cho CH, Koh YJ, Han J, Sung HK, Jong Lee H. 21.  et al. 2007. Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circul. Res. 100:e47–57 [Google Scholar]
22. Chun TH, Hotary KB, Sabeh F, Saltiel AR, Allen ED, Weiss SJ. 22.  2006. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125:577–91 [Google Scholar]
23. Chun TH, Inoue M, Morisaki H, Yamanaka I, Miyamoto Y. 23.  et al. 2010. Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. Diabetes 59:2484–94 [Google Scholar]
24. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E. 24.  et al. 2005. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46:2347–55 [Google Scholar]
25. Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM. 25.  2008. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR +CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood 112:3455–64 [Google Scholar]
26. Demeulemeester D, Collen D, Lijnen HR. 26.  2005. Effect of matrix metalloproteinase inhibition on adipose tissue development. Biochem. Biophys. Res. Commun. 329:105–10 [Google Scholar]
27. Demeulemeester D, Scroyen I, Voros G, Snoeys J, De Geest B. 27.  et al. 2006. Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in mice does not affect adipogenesis or adipose tissue development. Thromb. Haemost. 95:1019–24 [Google Scholar]
28. DiGirolamo M, Fine JB, Tagra K, Rossmanith R. 28.  1998. Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum. Am. J. Physiol. 274:R1460–67 [Google Scholar]
29. Dimaculangan DD, Chawla A, Boak A, Kagan HM, Lazar MA. 29.  1994. Retinoic acid prevents downregulation of RAS recision gene/lysyl oxidase early in adipocyte differentiation. Differentiation 58:47–52 [Google Scholar]
30. Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D. 30.  et al. 2010. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 59:2817–25 [Google Scholar]
31. Elias I, Franckhauser S, Ferre T, Vila L, Tafuro S. 31.  et al. 2012. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 61:1801–13 [Google Scholar]
32. Famulla S, Horrighs A, Cramer A, Sell H, Eckel J. 32.  2012. Hypoxia reduces the response of human adipocytes towards TNFα resulting in reduced NF-κB signaling and MCP-1 secretion. Int. J. Obes. 36:986–92 [Google Scholar]
33. Gealekman O, Guseva N, Hartigan C, Apotheker S, Gorgoglione M. 33.  et al. 2011. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation 123:186–94 [Google Scholar]
34. Giordano A, Murano I, Mondini E, Perugini J, Smorlesi A. 34.  et al. 2013. Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J. Lipid Res. 54:2423–36 [Google Scholar]
35. Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ. 35.  et al. 2012. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 15:230–39 [Google Scholar]
36. Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD. 36.  et al. 2009. Hypoxia-inducible factor 1α induces fibrosis and insulin resistance in white adipose tissue. Mol. Cell. Biol. 29:4467–83 [Google Scholar]
37. Hammarstedt A, Graham TE, Kahn BB. 37.  2012. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells. Diabetol. Metab. Syndr. 4:42 [Google Scholar]
38. Han J, Lee JE, Jin J, Lim JS, Oh N. 38.  et al. 2011. The spatiotemporal development of adipose tissue. Development 138:5027–37 [Google Scholar]
39. Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H. 39.  et al. 2011. Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch. Sci. Signal. 4:ra3 [Google Scholar]
40. Haro H, Crawford HC, Fingleton B, MacDougall JR, Shinomiya K. 40.  et al. 2000. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. J. Clin. Invest. 105:133–41 [Google Scholar]
41. Hausman GJ, Richardson RL. 41.  2004. Adipose tissue angiogenesis. J. Anim. Sci. 82:925–34 [Google Scholar]
42. He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. 42.  2011. Regulation of HIF-1α activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am. J. Physiol. Endocrinol. Metab. 300:E877–85 [Google Scholar]
43. He Y, Xu H, Liang L, Zhan Z, Yang X. 43.  et al. 2008. Antiinflammatory effect of Rho kinase blockade via inhibition of NF-κB activation in rheumatoid arthritis. Arthritis Rheum. 58:3366–76 [Google Scholar]
44. Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S. 44.  et al. 2007. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56:901–11 [Google Scholar]
45. Hossain MG, Iwata T, Mizusawa N, Shima SW, Okutsu T. 45.  et al. 2010. Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARγ2 and C/EBPα. J. Biosci. Bioeng. 109:297–303 [Google Scholar]
46. Huang HY, Chen SZ, Zhang WT, Wang SS, Liu Y. 46.  et al. 2013. Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment. Stem Cell Res. 10:278–87 [Google Scholar]
47. Isakson P, Hammarstedt A, Gustafson B, Smith U. 47.  2009. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-α, and inflammation. Diabetes 58:1550–57 [Google Scholar]
48. Jernas M, Palming J, Sjoholm K, Jennische E, Svensson PA. 48.  et al. 2006. Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J. 20:1540–42 [Google Scholar]
49. Kakudo N, Kushida S, Suzuki K, Ogura T, Notodihardjo PV. 49.  et al. 2012. Effects of transforming growth factor-β1 on cell motility, collagen gel contraction, myofibroblastic differentiation, and extracellular matrix expression of human adipose-derived stem cell. Hum. Cell 25:87–95 [Google Scholar]
50. Kanda T, Wakino S, Homma K, Yoshioka K, Tatematsu S. 50.  et al. 2006. Rho-kinase as a molecular target for insulin resistance and hypertension. FASEB J. 20:169–71 [Google Scholar]
51. Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LK, Frayn KN. 51.  2002. Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes 51:2467–73 [Google Scholar]
52. Keophiphath M, Achard V, Henegar C, Rouault C, Clement K, Lacasa D. 52.  2009. Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes. Mol. Endocrinol. 23:11–24 [Google Scholar]
53. Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M. 53.  et al. 2009. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol. Cell. Biol. 29:1575–91 [Google Scholar]
54. Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME. 54.  et al. 2007. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Invest. 117:2621–37 [Google Scholar]
55. Klingberg F, Hinz B, White ES. 55.  2013. The myofibroblast matrix: implications for tissue repair and fibrosis. J. Pathol. 229:298–309 [Google Scholar]
56. Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L. 56.  et al. 2010. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J. Clin. Invest. 120:756–67 [Google Scholar]
57. Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J. 57.  et al. 2010. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J. Clin. Invest. 120:3466–79 [Google Scholar]
58. Landskroner-Eiger S, Qian B, Muise ES, Nawrocki AR, Berger JP. 58.  et al. 2009. Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin. Cancer Res. 15:3265–76 [Google Scholar]
59. Lee MJ, Wu Y, Fried SK. 59.  2010. Adipose tissue remodeling in pathophysiology of obesity. Curr. Opin. Clin. Nutr. Metab. Care 13:371–76 [Google Scholar]
60. Lee SH, Lee JA, Park HS, Song YS, Jang YJ. 60.  et al. 2013. Associations among SPARC mRNA expression in adipose tissue, serum SPARC concentration, and metabolic parameters in Korean women. Obesity (Silver Spring) 21:2296–302 [Google Scholar]
61. Lee YH, Petkova AP, Granneman JG. 61.  2013. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab. 18:355–67 [Google Scholar]
62. Lee YH, Petkova AP, Mottillo EP, Granneman JG. 62.  2012. In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding. Cell Metab. 15:480–91 [Google Scholar]
63. Li J, Yu X, Pan W, Unger RH. 63.  2002. Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity. Am. J. Physiol. Endocrinol. Metab. 282:E1334–41 [Google Scholar]
64. Li Q, Hata A, Kosugi C, Kataoka N, Funaki M. 64.  2010. The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes. FEBS Lett. 584:4145–50 [Google Scholar]
65. Lijnen HR, Demeulemeester D, Van Hoef B, Collen D, Maquoi E. 65.  2003. Deficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice. Thromb. Haemost. 89:249–55 [Google Scholar]
66. Lijnen HR, Maquoi E, Hansen LB, Van Hoef B, Frederix L, Collen D. 66.  2002. Matrix metalloproteinase inhibition impairs adipose tissue development in mice. Arterioscler. Thromb. Vasc. Biol. 22:374–79 [Google Scholar]
67. Lumeng CN, Bodzin JL, Saltiel AR. 67.  2007. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117:175–84 [Google Scholar]
68. Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. 68.  2008. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57:3239–46 [Google Scholar]
69. MacLaren RE, Cui W, Lu H, Simard S, Cianflone K. 69.  2010. Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects. BMC Med. Genomics 3:3 [Google Scholar]
70. Manes S, Mira E, Barbacid MM, Cipres A, Fernandez-Resa P. 70.  et al. 1997. Identification of insulin-like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3. J. Biol. Chem. 272:25706–12 [Google Scholar]
71. Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. 71.  2013. Macrophage plasticity and polarization in tissue repair and remodelling. J. Pathol. 229:176–85 [Google Scholar]
72. Maquoi E, Munaut C, Colige A, Collen D, Lijnen HR. 72.  2002. Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes 51:1093–101 [Google Scholar]
73. McLaughlin T, Deng A, Yee G, Lamendola C, Reaven G. 73.  et al. 2010. Inflammation in subcutaneous adipose tissue: relationship to adipose cell size. Diabetologia 53:369–77 [Google Scholar]
74. McLaughlin T, Sherman A, Tsao P, Gonzalez O, Yee G. 74.  et al. 2007. Enhanced proportion of small adipose cells in insulin-resistant versus insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia 50:1707–15 [Google Scholar]
75. Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C. 75.  2011. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia 54:1468–79 [Google Scholar]
76. Menghini R, Casagrande V, Menini S, Marino A, Marzano V. 76.  et al. 2012. TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. Diabetes 61:454–62 [Google Scholar]
77. Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V. 77.  et al. 2009. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 136:663–72.e4 [Google Scholar]
78. Molina H, Yang Y, Ruch T, Kim JW, Mortensen P. 78.  et al. 2009. Temporal profiling of the adipocyte proteome during differentiation using a five-plex SILAC based strategy. J. Proteome Res. 8:48–58 [Google Scholar]
79. Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ. 79.  et al. 2011. Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev. Res. 4:1021–29 [Google Scholar]
80. Nagase H, Visse R, Murphy G. 80.  2006. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res. 69:562–73 [Google Scholar]
81. Nakajima I, Muroya S, Tanabe R, Chikuni K. 81.  2002. Extracellular matrix development during differentiation into adipocytes with a unique increase in type V and VI collagen. Biol. Cell 94:197–203 [Google Scholar]
82. Nakayama Y, Komuro R, Yamamoto A, Miyata Y, Tanaka M. 82.  et al. 2009. RhoA induces expression of inflammatory cytokine in adipocytes. Biochem. Biophys. Res. Commun. 379:288–92 [Google Scholar]
83. Nie J, Bradshaw AD, Delany AM, Sage EH. 83.  2011. Inactivation of SPARC enhances high-fat diet-induced obesity in mice. Connect. Tissue Res. 52:99–108 [Google Scholar]
84. Nie J, Sage EH. 84.  2009. SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling. J. Biol. Chem. 284:1279–90 [Google Scholar]
85. Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H. 85.  et al. 2007. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 56:1517–26 [Google Scholar]
86. Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H. 86.  et al. 2008. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J. Clin. Invest. 118:710–21 [Google Scholar]
87. Noe V, Fingleton B, Jacobs K, Crawford HC, Vermeulen S. 87.  et al. 2001. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J. Cell Sci. 114:111–18 [Google Scholar]
88. O'Brien J, Martinson H, Durand-Rougely C, Schedin P. 88.  2012. Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution. Development 139:269–75 [Google Scholar]
89. O'Hara A, Lim FL, Mazzatti DJ, Trayhurn P. 89.  2009. Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned medium. Pflügers Arch. 458:1103–14 [Google Scholar]
90. O'Rourke RW, White AE, Metcalf MD, Olivas AS, Mitra P. 90.  et al. 2011. Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells. Diabetologia 54:1480–90 [Google Scholar]
91. Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky JM. 91.  2012. Increased macrophage migration into adipose tissue in obese mice. Diabetes 61:346–54 [Google Scholar]
92. Papetti M, Herman IM. 92.  2002. Mechanisms of normal and tumor-derived angiogenesis. Am. J. Physiol. Cell Physiol. 282:C947–70 [Google Scholar]
93. Park D, Yoon M. 93.  2012. Compound K, a novel ginsenoside metabolite, inhibits adipocyte differentiation in 3T3-L1 cells: involvement of angiogenesis and MMPs. Biochem. Biophys. Res. Commun. 422:263–67 [Google Scholar]
94. Pasarica M, Gowronska-Kozak B, Burk D, Remedios I, Hymel D. 94.  et al. 2009. Adipose tissue collagen VI in obesity. J. Clin. Endocrinol. Metab. 94:5155–62 [Google Scholar]
95. Pasarica M, Rood J, Ravussin E, Schwarz JM, Smith SR, Redman LM. 95.  2010. Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis. J. Clin. Endocrinol. Metab. 95:4052–55 [Google Scholar]
96. Pasarica M, Sereda OR, Redman LM, Albarado DC, Hymel DT. 96.  et al. 2009. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58:718–25 [Google Scholar]
97. Pierleoni C, Verdenelli F, Castellucci M, Cinti S. 97.  1998. Fibronectins and basal lamina molecules expression in human subcutaneous white adipose tissue. Eur. J. Histochem. 42:183–88 [Google Scholar]
98. Ptitsyn A, Hulver M, Cefalu W, York D, Smith SR. 98.  2006. Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome. BMC Genomics 7:318 [Google Scholar]
99. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ. 99.  et al. 2004. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109:1292–98 [Google Scholar]
100. Ribatti D, Conconi MT, Nussdorfer GG. 100.  2007. Nonclassic endogenous novel [corrected] regulators of angiogenesis. Pharmacol. Rev. 59:185–205 [Google Scholar]
101. Rodeheffer MS, Birsoy K, Friedman JM. 101.  2008. Identification of white adipocyte progenitor cells in vivo. Cell 135:240–49 [Google Scholar]
102. Rosen ED, MacDougald OA. 102.  2006. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7:885–96 [Google Scholar]
103. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB. 103.  et al. 2002. Adipose tissue mass can be regulated through the vasculature. Proc. Natl. Acad. Sci. USA 99:10730–35 [Google Scholar]
104. Sage EH, Bornstein P. 104.  1991. Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin. J. Biol. Chem. 266:14831–34 [Google Scholar]
105. Schonbeck U, Mach F, Libby P. 105.  1998. Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. J. Immunol. 161:3340–46 [Google Scholar]
106. Sharma NS, Nagrath D, Yarmush ML. 106.  2010. Adipocyte-derived basement membrane extract with biological activity: applications in hepatocyte functional augmentation in vitro. FASEB J. 24:2364–74 [Google Scholar]
107. Shaul ME, Bennett G, Strissel KJ, Greenberg AS, Obin MS. 107.  2010. Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice. Diabetes 59:1171–81 [Google Scholar]
108. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA. 108.  et al. 2008. Dynamics of fat cell turnover in humans. Nature 453:783–87 [Google Scholar]
109. Spencer M, Unal R, Zhu B, Rasouli N, McGehee RE Jr. 109.  et al. 2011. Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. J. Clin. Endocrinol. Metab. 96:E1990–98 [Google Scholar]
110. Spencer M, Yao-Borengasser A, Unal R, Rasouli N, Gurley CM. 110.  et al. 2010. Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am. J. Physiol. Endocrinol. Metab. 299:E1016–27 [Google Scholar]
111. Suganami T, Ogawa Y. 111.  2010. Adipose tissue macrophages: their role in adipose tissue remodeling. J. Leukocyte Biol. 88:33–39 [Google Scholar]
112. Sun K, Kusminski CM, Scherer PE. 112.  2011. Adipose tissue remodeling and obesity. J. Clin. Invest. 121:2094–101 [Google Scholar]
113. Sun K, Tordjman J, Clement K, Scherer PE. 113.  2013. Fibrosis and adipose tissue dysfunction. Cell Metab. 18:470–77 [Google Scholar]
114. Sung HK, Doh KO, Son JE, Park JG, Bae Y. 114.  et al. 2013. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab. 17:61–72 [Google Scholar]
115. Tam CS, Tordjman J, Divoux A, Baur LA, Clement K. 115.  2012. Adipose tissue remodeling in children: the link between collagen deposition and age-related adipocyte growth. J. Clin. Endocrinol. Metab. 97:1320–27 [Google Scholar]
116. Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D, Jain RK. 116.  2009. Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells. PLoS ONE 4:e4974 [Google Scholar]
117. Tanabe Y, Koga M, Saito M, Matsunaga Y, Nakayama K. 117.  2004. Inhibition of adipocyte differentiation by mechanical stretching through ERK-mediated downregulation of PPARγ2. J. Cell Sci. 117:3605–14 [Google Scholar]
118. Tang W, Zeve D, Seo J, Jo AY, Graff JM. 118.  2011. Thiazolidinediones regulate adipose lineage dynamics. Cell Metab. 14:116–22 [Google Scholar]
119. Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M. 119.  et al. 2008. White fat progenitor cells reside in the adipose vasculature. Science 322:583–86 [Google Scholar]
120. Tran KV, Gealekman O, Frontini A, Zingaretti MC, Morroni M. 120.  et al. 2012. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 15:222–29 [Google Scholar]
121. Unger RH, Scherer PE. 121.  2010. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol. Metab. 21:345–52 [Google Scholar]
122. Van Hul M, Bauters D, Lijnen RH. 122.  2013. Differential effects of a gelatinase inhibitor on adipocyte differentiation and adipose tissue development. Clin. Exp. Pharmacol. Physiol. 40:689–97 [Google Scholar]
123. Van Hul M, Lijnen HR. 123.  2008. A functional role of gelatinase A in the development of nutritionally induced obesity in mice. J. Thromb. Haemost. 6:1198–206 [Google Scholar]
124. Verstappen J, Von den Hoff JW. 124.  2006. Tissue inhibitors of metalloproteinases (TIMPs): their biological functions and involvement in oral disease. J. Dent. Res. 85:1074–84 [Google Scholar]
125. Virtanen KA, Lonnroth P, Parkkola R, Peltoniemi P, Asola M. 125.  et al. 2002. Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J. Clin. Endocrinol. Metab. 87:3902–10 [Google Scholar]
126. Visse R, Nagase H. 126.  2003. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ. Res. 92:827–39 [Google Scholar]
127. Vona-Davis L, Howard-McNatt M, Rose DP. 127.  2007. Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer. Obes. Rev. 8:395–408 [Google Scholar]
128. Vona-Davis L, Rose DP. 128.  2009. Angiogenesis, adipokines and breast cancer. Cytokine Growth Factor Rev. 20:193–201 [Google Scholar]
129. Wang QA, Tao C, Gupta RK, Scherer PE. 129.  2013. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19:1338–44 [Google Scholar]
130. Wentworth JM, Naselli G, Brown WA, Doyle L, Phipson B. 130.  et al. 2010. Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes 59:1648–56 [Google Scholar]
131. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan H. 131.  et al. 2011. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332:243–47 [Google Scholar]
132. Ye J, Gao Z, Yin J, He Q. 132.  2007. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metab. 293:E1118–28 [Google Scholar]
133. Yu Q, Stamenkovic I. 133.  2000. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev. 14:163–76 [Google Scholar]