Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced          uveitis in Lewis rats

Kazutaka KANAI; Sho NAGATA; Takuya HATTA; Yuichi SUGIURA; Kazuaki SATO; Yohei YAMASHITA; Yuya KIMURA; Naoyuki ITOH

doi:10.1292/jvms.16-0196

Clinical Pathology

Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats

Kazutaka KANAI, Sho NAGATA, Takuya HATTA, Yuichi SUGIURA, Kazuaki SATO, Yohei YAMASHITA, Yuya KIMURA, Naoyuki ITOH

Author information

Kazutaka KANAI
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan
Sho NAGATA
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan
Takuya HATTA
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan
Yuichi SUGIURA
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan
Kazuaki SATO
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan
Yohei YAMASHITA
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan
Yuya KIMURA
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan
Naoyuki ITOH
Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan

Keywords: anti-inflammatory effect, endotoxin-induced uveitis, luteolin, prednisolone, therapeutic effect

JOURNAL FREE ACCESS

2016 Volume 78 Issue 8 Pages 1381-1384

DOI https://doi.org/10.1292/jvms.16-0196

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Abstract

The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 µg) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.

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