Abstract
Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (vIRFs). This review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of KSHV and related vIRFs.
About the authors
Sandra Koch is a PhD student in the Institute of Virology at Hannover Medical School. Under the supervision of Professor Thomas F. Schulz, she is working on the establishment of latency and the mechanisms of lytic reactivation of Kaposi’s sarcoma-associated herpesvirus. She received her Master’s degree in Biology with a focus on infection and cell biology in 2013 from the Technical University Braunschweig. In 2011 Sandra Koch obtained her Bachelor’s degree in Biotechnology after 3 years of practice related studying from the University of Applied Sciences in Darmstadt.
Thomas F. Schulz is Professor of Virology and Head of the Institute of Virology at Hannover Medical School. He obtained his medical doctorate in 1980, his ‘Habilitation’ in Innsbruck in 1986 and his board certification in Medical Microbiology and Virology in 1990. He worked at the Institute of Microbiology in Mainz, the Instute of Hygiene in Innsbruck, the Institute of Cancer Research in London and became a professor in the Department of Microbiology of the University of Liverpool in 1995. In 2000 he moved to Hannover to assume his current position. Since 1995 his research has focused on Kaposi’s sarcoma herpesvirus, in particular on its epidemiology, its mechanisms of latent persistence and reactivation and its oncogenic properties.
Acknowledgments
This work was funded by the Deutsche Forschungsgemeinschaft, grant SCHU-1668/3-1 and by the Collaborative Research Centre 900, project C1. We thank Elias Hage and Akshay Dhingra for help with sequence alignments and phylogenetic trees.
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