Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
Decreased Serum Fetuin-A Levels are Associated with Coronary Artery Diseases
Oktay BilgirLevent KebapcilarFerda BilgirGiray BozkayaYasar YildizPelin PinarAhmet Tastan
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JOURNAL OPEN ACCESS

2010 Volume 49 Issue 13 Pages 1281-1285

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Abstract

Background To analyze Fetuin-A levels and soluble cellular adhesion molecules in patients with acute coronary syndrome.
Methods and Results Serum Fetuin-A and intercellular adhesion molecule-1 (sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1) levels were examined in 127 patients who presented with chest pain. These patients were classified in three groups: stable angina (SA, n=51), myocardial infarction (MI, n=34) and non-cardiac group (n=42). Logarithmic transformations were made for Fetuin-A levels. Log-Fetuin-A levels were higher in non-cardiac subjects compared to MI and SA patients (p<0.05). Patients with SA showed lower levels than controls but higher levels as compared to MI patients. After controlling for age and gender, levels of sVCAM-1 and sICAM-1 in patients with coronary atherosclerosis were not different from those in non-cardiac subjects.
Conclusion Serum levels of soluble VCAM-1, ICAM-1 were not related to coronary artery disease (CAD), but fetuin-A levels seems to be decreased in SA and MI patients. Low fetuin-A may play a role in the pathophysiology of CAD.

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© 2010 by The Japanese Society of Internal Medicine
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