The Ripostatins, Novel Inhibitors of Eubacterial RNA Polymerase Isolated from Myxobacteria

HERBERT IRSCHIK; HERMANN AUGUSTINIAK; KLAUS GERTH; GERHARD HÖFLE; HANS REICHENBACH

doi:10.7164/antibiotics.48.787

HERBERT IRSCHIK, HERMANN AUGUSTINIAK, KLAUS GERTH, GERHARD HÖFLE, HANS REICHENBACH

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 8 Pages 787-792

DOI https://doi.org/10.7164/antibiotics.48.787

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Abstract

A new antibiotic, ripostatin, was isolated from the culture supernatant of the myxobacterium, Sorangium cellulosum strain So ce377. It is a macrocyclic lactone carbonic acid containing an unsubstituted phenyl ring in a side chain. The antibiotic acts especially on Staphylococcus aureus, but seems not to penetrate most bacteria.
The MIC values are in the range of 1 μg/ml. Ripostatin is an inhibitor of eubacterial RNA polymerase. It interferes with the initiation of RNA synthesis.

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