Pathoadaptive mutations: gene loss and variation in bacterial pathogens

E V Sokurenko; D L Hasty; D E Dykhuizen

doi:10.1016/s0966-842x(99)01493-6

Pathoadaptive mutations: gene loss and variation in bacterial pathogens

Trends Microbiol. 1999 May;7(5):191-5. doi: 10.1016/s0966-842x(99)01493-6.

Authors

E V Sokurenko¹, D L Hasty, D E Dykhuizen

Affiliation

¹ Dept of Microbiology, University of Washington, Seattle, WA 98195, USA.evs@u.washington.edu

PMID: 10354593
DOI: 10.1016/s0966-842x(99)01493-6

Abstract

Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adaptation, Physiological
Bacterial Physiological Phenomena*
Evolution, Molecular
Genes, Bacterial*
Genetic Variation
Humans
Mutation*