MLL2: A new mammalian member of the trx/MLL family of genes

Genomics. 1999 Jul 15;59(2):187-92. doi: 10.1006/geno.1999.5860.

Abstract

We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Expression
  • Genes / genetics*
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Male
  • Molecular Sequence Data
  • Myeloid-Lymphoid Leukemia Protein
  • Neoplasm Proteins*
  • Proto-Oncogenes*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Transcription Factors*

Substances

  • DNA, Complementary
  • DNA-Binding Proteins
  • KMT2A protein, human
  • KMT2D protein, human
  • Neoplasm Proteins
  • RNA, Messenger
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase

Associated data

  • GENBANK/AF104918
  • GENBANK/AF105279
  • GENBANK/AF105280