Abstract
The structural and physico-chemical parameters promoting the binding of aminoglycosides to RNAs are becoming clear. The strength of the interaction is dominated by electrostatics, with the positively charged aminoglycosides displacing metal ions. Although aminoglycosides inhibit most known ribozymes, aminoglycosides or polyamines are able to catalyze specific RNA cleavage in the absence of metal ions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aminoglycosides
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Carbohydrate Sequence
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Molecular Sequence Data
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RNA / chemistry
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RNA / drug effects*
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RNA / metabolism
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RNA, Catalytic / antagonists & inhibitors
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RNA, Catalytic / drug effects
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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RNA, Catalytic
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RNA