Cycling lipids

Curr Biol. 2000 Jan 27;10(2):R57-9. doi: 10.1016/s0960-9822(00)00279-7.

Abstract

When synaptic vesicles fuse with the presynaptic plasma membrane, their membrane constituents are recycled by internalisation into clathrin-coated vesicles. To form new synaptic vesicles, the clathrin coat must be shed and recent studies reveal that a lipid phosphatase, synaptojanin, plays a central role in this process.

Publication types

  • Review

MeSH terms

  • Calcium-Binding Proteins*
  • Clathrin / metabolism
  • Exocytosis
  • Membrane Fusion
  • Membrane Glycoproteins / metabolism
  • Membrane Lipids / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Synaptotagmins

Substances

  • Calcium-Binding Proteins
  • Clathrin
  • Membrane Glycoproteins
  • Membrane Lipids
  • Nerve Tissue Proteins
  • Synaptotagmins