Abstract
Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Division
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Cellular Senescence
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Fibroblasts / cytology
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Humans
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Mice
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Mice, Knockout
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Neoplasms / etiology*
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Neoplasms / prevention & control*
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Species Specificity
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Telomerase / genetics
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Telomerase / physiology
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Telomere / physiology*