Functional domains of the ATPase inhibitor protein from bovine heart mitochondria

F Zanotti; G Raho; R Vuolo; A Gaballo; F Papa; S Papa

doi:10.1016/s0014-5793(00)02055-x

Functional domains of the ATPase inhibitor protein from bovine heart mitochondria

FEBS Lett. 2000 Sep 29;482(1-2):163-6. doi: 10.1016/s0014-5793(00)02055-x.

Authors

F Zanotti¹, G Raho, R Vuolo, A Gaballo, F Papa, S Papa

Affiliation

¹ Department of Medical Biochemistry and Biology, University of Bari, Italy.

PMID: 11018542
DOI: 10.1016/s0014-5793(00)02055-x

Abstract

A study is presented of the activity and temperature dependence of the ATPase inhibitor protein (IF(1)) from bovine heart mitochondria and of synthetic partial IF(1) peptides. The results show that the IF(1)-(42-58) peptide is the most potent inhibitory domain of IF(1).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATPase Inhibitory Protein
Adenosine Triphosphatases / antagonists & inhibitors*
Amino Acid Sequence
Animals
Cattle
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / isolation & purification
Intracellular Membranes / chemistry
Intracellular Membranes / metabolism
Kinetics
Mitochondria, Heart / chemistry
Mitochondria, Heart / metabolism*
Molecular Sequence Data
Peptide Fragments / chemistry*
Peptide Fragments / pharmacology
Proteins / chemistry*
Proteins / isolation & purification
Proteins / metabolism*
Thermodynamics

Substances

Enzyme Inhibitors
Peptide Fragments
Proteins
Adenosine Triphosphatases