Abstract
The activation of membrane-bound transcription factors involves release from the membrane by proteolysis. Recent studies show that, for some proteins, cleavage is performed by the proteasome, whereas others require specific proteases.
MeSH terms
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Animals
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CCAAT-Enhancer-Binding Proteins / genetics
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CCAAT-Enhancer-Binding Proteins / metabolism*
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Cell Membrane / metabolism*
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Cysteine Endopeptidases / metabolism
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Fatty Acids, Unsaturated / metabolism
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Gene Expression Regulation*
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Humans
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Multienzyme Complexes / metabolism
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Proteasome Endopeptidase Complex
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Transcription, Genetic*
Substances
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CCAAT-Enhancer-Binding Proteins
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DNA-Binding Proteins
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Fatty Acids, Unsaturated
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Multienzyme Complexes
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SREBF1 protein, human
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors
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Cysteine Endopeptidases
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Proteasome Endopeptidase Complex