Abstract
The DnaJ protein auxilin has been extensively studied in vitro as a cofactor for uncoating clathrin-coated vesicles by the chaperone Hsc70. Recent studies provide the first evidence that auxilin plays this role in vivo, and work on a new mammalian auxilin suggests the protein may have more complex cellular functions.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Vesicular Transport
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Amino Acid Sequence
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Clathrin / physiology*
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / physiology*
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Phosphoproteins / chemistry
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Phosphoproteins / physiology*
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Sequence Homology, Amino Acid
Substances
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Adaptor Proteins, Vesicular Transport
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Clathrin
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Nerve Tissue Proteins
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Phosphoproteins