Abstract
Amentoflavone and three other flavonoids were isolated from the ethanol extract of Selaginella sinensis. Amentoflavone showed potent antiviral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 microg/ml. The contents of amentoflavone in nine species of Selaginella were determined by reversed-phase HPLC. S. sinensis showed a higher content of 1.13%.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology*
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Biflavonoids*
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China
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Chromatography, High Pressure Liquid
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Plants, Medicinal / chemistry*
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Respiratory Syncytial Virus, Human / drug effects
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Species Specificity
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Antiviral Agents
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Biflavonoids
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Flavonoids
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amentoflavone