Abstract
The effects of age on serotonergic function have been hypothesized to underlie age-related changes in mood and behaviors such as sleep and eating. Of particular interest is the serotonin type-1A (5-HT1A) receptor, due to its putative role in mediating the therapeutic efficacy of antidepressant treatment. Using positron emission tomography (PET) and [11C--carbonyl] WAY100635, we assessed 5-HT1A receptor binding in 21 healthy subjects (10 men, 11 women) ranging in age from 21 to 80 years. Regional binding potential values were generated using a reference tissue model and corrected for partial volume effects. We observed an inverse relationship between age and binding of [11C--carbonyl] WAY100635 to the 5-HT1A receptor in men, but not women. This finding is in accord with observations reported in the postmortem literature. Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Age Factors
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Aged
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Aged, 80 and over
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Aging / drug effects
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Aging / metabolism*
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Antidepressive Agents, Second-Generation / pharmacokinetics
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Binding Sites / drug effects
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Binding Sites / physiology
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Brain / anatomy & histology
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Brain / drug effects
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Brain / metabolism*
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Brain Chemistry / physiology*
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Carbon Radioisotopes / pharmacokinetics
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Cerebrovascular Circulation / physiology
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Female
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Humans
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Male
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Middle Aged
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Mood Disorders / drug therapy
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Mood Disorders / metabolism
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Mood Disorders / physiopathology
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Piperazines / pharmacokinetics
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Pyridines / pharmacokinetics
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism*
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Receptors, Serotonin, 5-HT1
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Serotonin Antagonists / pharmacokinetics
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Sex Factors
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Tomography, Emission-Computed
Substances
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Antidepressive Agents, Second-Generation
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Carbon Radioisotopes
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Piperazines
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Pyridines
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Serotonin Antagonists
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N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide