Notch pathway: making sense of suppressor of hairless

Curr Biol. 2001 Mar 20;11(6):R217-21. doi: 10.1016/s0960-9822(01)00109-9.

Abstract

Suppressor of Hairless (Su(H)) is a DNA-binding protein component of the Notch signalling pathway, thought to be required, with a fragment of the Notch receptor, for target gene activation. Recent studies show that this is only one side of the story: target gene enhancers may be regulated by Su(H) in a variety of different ways.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Drosophila Proteins*
  • Enhancer Elements, Genetic
  • Gene Expression Regulation
  • Helix-Loop-Helix Motifs
  • Insect Proteins / genetics
  • Membrane Proteins / metabolism*
  • Nuclear Proteins / genetics
  • Receptors, Notch
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Signal Transduction / physiology*
  • Transcriptional Activation

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins
  • Drosophila Proteins
  • E(spl)mdelta-HLH protein, Drosophila
  • Insect Proteins
  • Membrane Proteins
  • Nuclear Proteins
  • Receptors, Notch
  • Repressor Proteins
  • Su(H) protein, Drosophila
  • sim protein, Drosophila
  • vg protein, Drosophila