Abstract
Suppressor of Hairless (Su(H)) is a DNA-binding protein component of the Notch signalling pathway, thought to be required, with a fragment of the Notch receptor, for target gene activation. Recent studies show that this is only one side of the story: target gene enhancers may be regulated by Su(H) in a variety of different ways.
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Drosophila Proteins*
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Enhancer Elements, Genetic
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Gene Expression Regulation
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Helix-Loop-Helix Motifs
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Insect Proteins / genetics
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Membrane Proteins / metabolism*
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Nuclear Proteins / genetics
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Receptors, Notch
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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Signal Transduction / physiology*
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Transcriptional Activation
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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Drosophila Proteins
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E(spl)mdelta-HLH protein, Drosophila
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Insect Proteins
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Membrane Proteins
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Nuclear Proteins
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Receptors, Notch
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Repressor Proteins
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Su(H) protein, Drosophila
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sim protein, Drosophila
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vg protein, Drosophila