Regulation and function of the p53 tumor suppressor protein

K M Ryan; A C Phillips; K H Vousden

doi:10.1016/s0955-0674(00)00216-7

Regulation and function of the p53 tumor suppressor protein

Curr Opin Cell Biol. 2001 Jun;13(3):332-7. doi: 10.1016/s0955-0674(00)00216-7.

Authors

K M Ryan¹, A C Phillips, K H Vousden

Affiliation

¹ Regulation of Cell Growth Laboratory, Building 560, Room 22-96, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

PMID: 11343904
DOI: 10.1016/s0955-0674(00)00216-7

Abstract

Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Active Transport, Cell Nucleus / physiology
Animals
Apoptosis / physiology*
Cell Compartmentation / physiology*
Cell Cycle / physiology
Cell Division / physiology
Gene Expression Regulation, Neoplastic / genetics
Gene Expression Regulation, Neoplastic / physiology
Humans
Mutation / genetics
Neoplasms / pathology*
Neoplasms / physiopathology*
Transcription Factors / genetics
Transcription Factors / metabolism
Transcription, Genetic / genetics
Transcription, Genetic / physiology*
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism*

Substances

Transcription Factors
Tumor Suppressor Protein p53