Abstract
During normal vertebrate development, hematopoietic and endothelial cells form closely situated and interacting populations. Although the close proximity of cells to each other does not necessarily mean that they are relatives, accumulating evidence indicates that hematopoietic and endothelial cells are indeed close kin; they share common progenitors and each is able to become the other under certain circumstances. This article summarizes recent advances in the developmental relationship between hematopoietic and endothelial cells.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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Bone Marrow / growth & development*
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Cell Differentiation
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Cell Lineage
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins / physiology
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Drosophila / growth & development
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Endothelium, Vascular / growth & development*
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Hematopoiesis
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Hematopoietic Stem Cells / physiology*
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LIM Domain Proteins
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Metalloproteins / physiology
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Mice
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Models, Biological
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Proto-Oncogene Proteins*
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T-Cell Acute Lymphocytic Leukemia Protein 1
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Transcription Factors / physiology
Substances
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Adaptor Proteins, Signal Transducing
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Basic Helix-Loop-Helix Transcription Factors
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins
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LIM Domain Proteins
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Lmo2 protein, mouse
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Metalloproteins
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Proto-Oncogene Proteins
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Runx1 protein, mouse
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T-Cell Acute Lymphocytic Leukemia Protein 1
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Tal1 protein, mouse
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Transcription Factors