Abstract
The nodal family of TGFbeta-related ligands have emerged as critical regulators of early vertebrate embryogenesis. Recent studies in mice, fish, and frogs of nodals and their intracellular transducers allow a comparison of how this signaling pathway is used in the patterning of early embryos of these different vertebrates.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Body Patterning
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Feedback, Physiological
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Forkhead Transcription Factors
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Mice
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Nodal Protein
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Receptors, Transforming Growth Factor beta / metabolism
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Signal Transduction*
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transforming Growth Factor beta / metabolism*
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Vertebrates / embryology*
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Vertebrates / genetics
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Xenopus laevis / embryology
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Xenopus laevis / genetics
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Xenopus laevis / metabolism
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Zebrafish / embryology
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Zebrafish / genetics
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Zebrafish / metabolism
Substances
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DNA-Binding Proteins
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Forkhead Transcription Factors
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Foxh1 protein, mouse
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Nodal Protein
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Nodal protein, mouse
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Receptors, Transforming Growth Factor beta
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Transcription Factors
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Transforming Growth Factor beta