Network dynamics and cell physiology

Nat Rev Mol Cell Biol. 2001 Dec;2(12):908-16. doi: 10.1038/35103078.

Abstract

Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell, such as metabolism, DNA synthesis, movement and information processing. These physiological properties play out as a subtle molecular dance, choreographed by underlying regulatory networks. To understand this dance, a new breed of theoretical molecular biologists reproduces these networks in computers and in the mathematical language of dynamical systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • CDC2 Protein Kinase / genetics
  • CDC2 Protein Kinase / physiology
  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Cell Physiological Phenomena*
  • Computer Simulation
  • Macromolecular Substances
  • Models, Biological*
  • Mutation
  • Phenotype
  • Schizosaccharomyces / cytology
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces / physiology
  • Schizosaccharomyces pombe Proteins / genetics
  • Schizosaccharomyces pombe Proteins / physiology
  • Systems Theory

Substances

  • Macromolecular Substances
  • Schizosaccharomyces pombe Proteins
  • CDC2 Protein Kinase