Recognition of specific DNA sequences

Mol Cell. 2001 Nov;8(5):937-46. doi: 10.1016/s1097-2765(01)00392-6.

Abstract

Proteins that recognize specific DNA sequences play a central role in the regulation of transcription. The tremendous increase in structural information on protein-DNA complexes has uncovered a remarkable structural diversity in DNA binding folds, while at the same time revealing common themes in binding to target sites in the genome.

Publication types

  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Base Sequence / genetics
  • DNA / chemistry*
  • DNA / genetics
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • Models, Molecular
  • Nucleic Acid Conformation
  • Protein Binding
  • Protein Folding
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Zinc / metabolism

Substances

  • DNA-Binding Proteins
  • DNA
  • Zinc