Abstract
Proteins that recognize specific DNA sequences play a central role in the regulation of transcription. The tremendous increase in structural information on protein-DNA complexes has uncovered a remarkable structural diversity in DNA binding folds, while at the same time revealing common themes in binding to target sites in the genome.
MeSH terms
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Amino Acid Motifs
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Animals
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Base Sequence / genetics
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DNA / chemistry*
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DNA / genetics
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DNA / metabolism
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism*
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Models, Molecular
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Nucleic Acid Conformation
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Protein Binding
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Protein Folding
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Zinc / metabolism
Substances
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DNA-Binding Proteins
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DNA
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Zinc