Abstract
Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Active Transport, Cell Nucleus / physiology*
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Animals
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Fungal Proteins / metabolism
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Heterogeneous-Nuclear Ribonucleoproteins
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Humans
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Models, Biological
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Nuclear Proteins / metabolism*
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RNA Precursors / metabolism*
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RNA Splicing*
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / metabolism*
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Ribonucleoproteins / metabolism
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Spliceosomes / metabolism
Substances
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Fungal Proteins
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Heterogeneous-Nuclear Ribonucleoproteins
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Nuclear Proteins
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RNA Precursors
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RNA, Messenger
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RNA-Binding Proteins
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Ribonucleoproteins