A conserved mRNA export machinery coupled to pre-mRNA splicing

Cell. 2002 Feb 22;108(4):523-31. doi: 10.1016/s0092-8674(02)00627-x.

Abstract

Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology*
  • Animals
  • Fungal Proteins / metabolism
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Humans
  • Models, Biological
  • Nuclear Proteins / metabolism*
  • RNA Precursors / metabolism*
  • RNA Splicing*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Ribonucleoproteins / metabolism
  • Spliceosomes / metabolism

Substances

  • Fungal Proteins
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Nuclear Proteins
  • RNA Precursors
  • RNA, Messenger
  • RNA-Binding Proteins
  • Ribonucleoproteins