Molecular mechanisms of cancer pain

Patrick W Mantyh; Denis R Clohisy; Martin Koltzenburg; Steve P Hunt

doi:10.1038/nrc747

Molecular mechanisms of cancer pain

Nat Rev Cancer. 2002 Mar;2(3):201-9. doi: 10.1038/nrc747.

Authors

Patrick W Mantyh¹, Denis R Clohisy, Martin Koltzenburg, Steve P Hunt

Affiliation

¹ Department of Preventive Sciences, University of Minnesota, Minneapolis 55455, USA. manty001@tc.umn.edu

PMID: 11990856
DOI: 10.1038/nrc747

Abstract

Pain is the most disruptive influence on the quality of life of cancer patients. Although significant advances are being made in cancer treatment and diagnosis, the basic neurobiology of cancer pain is poorly understood. New insights into these mechanisms are now arising from animal models, and have the potential to fundamentally change the way that cancer pain is controlled.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Afferent Pathways / physiopathology*
Humans
Neoplasms / physiopathology*
Neurons, Afferent / physiology
Nociceptors / physiology
Pain*