Abstract
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism
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Gastrula / physiology*
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Glycoproteins / metabolism
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Ligands
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Models, Biological
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Mutation
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Phenotype
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Proto-Oncogene Proteins / metabolism*
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Signal Transduction*
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Wnt Proteins
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Xenopus / embryology*
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Xenopus Proteins
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Zebrafish / embryology*
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Zebrafish Proteins*
Substances
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Glycoproteins
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Ligands
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Proto-Oncogene Proteins
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Wnt Proteins
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Wnt11 protein, zebrafish
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Xenopus Proteins
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Zebrafish Proteins
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wnt11b protein, Xenopus
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wnt8b protein, zebrafish
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Calcium