Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud

Dennis Summerbell; Chandrika Halai; Peter W J Rigby

doi:10.1016/s0925-4773(02)00208-3

Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud

Mech Dev. 2002 Sep;117(1-2):331-5. doi: 10.1016/s0925-4773(02)00208-3.

Authors

Dennis Summerbell¹, Chandrika Halai, Peter W J Rigby

Affiliation

¹ Division of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

PMID: 12204280
DOI: 10.1016/s0925-4773(02)00208-3

Abstract

The development of skeletal muscle in vertebrate embryos is controlled by a transcriptional cascade involving the four myogenic regulatory factors. In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD. We have re-examined the expression pattern of Mrf4 and show that in the hypaxial domain of thoracic somites (the somitic bud) Mrf4 expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA-Binding Proteins*
Gene Expression Regulation, Developmental
In Situ Hybridization
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Muscle Development / genetics*
Muscle Proteins / genetics*
Muscle, Skeletal / embryology
Muscle, Skeletal / metabolism
Myogenic Regulatory Factor 5
Myogenic Regulatory Factors / genetics*
Myogenin
Somites / metabolism*
Trans-Activators*

Substances

DNA-Binding Proteins
Muscle Proteins
Myf5 protein, mouse
Myog protein, mouse
Myogenic Regulatory Factor 5
Myogenic Regulatory Factors
Myogenin
Trans-Activators
myogenic factor 6