Abstract
Viruses have evolved mechanisms to avoid the host immune system, including means of escaping detection by both the innate and adaptive immune responses. Natural killer (NK) cells are a central component of the innate immune system and are crucial in defense against certain viruses. To attain a state of chronic infection, some successful viruses have developed specific mechanisms to evade detection by and activation of NK cells. These NK cell-specific evasion mechanisms fall into distinct mechanistic categories used in numerous virus families.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Viral / genetics
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Antigens, Viral / immunology
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Chemokines / physiology
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Cytokines / genetics
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Cytokines / physiology
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Cytotoxicity, Immunologic
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Down-Regulation
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Gene Expression Regulation, Viral
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Genes, MHC Class I
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Histocompatibility Antigens Class I / immunology
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Humans
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / virology
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Mice
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Models, Immunological
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Receptors, Immunologic / genetics
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Receptors, Immunologic / physiology
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Virus Diseases / immunology
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Viruses / genetics
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Viruses / immunology*
Substances
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Antigens, Viral
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Chemokines
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Cytokines
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Histocompatibility Antigens Class I
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Receptors, Immunologic