Abstract
In this report, the authors propose that underlying sex differences in the biobehavioral response to stress may contribute to the variance in prevalence of some psychiatric disorders based on sex. The authors begin with a discussion of stress physiology and review a new theory on sex differences in stress responses (ie, the "tend-and-befriend" response), which may provide a recent framework for considering sex differences in the manifestation of some psychiatric illnesses. The authors then move to a discussion of major depression and attention deficit hyperactivity disorder as examples of how sex differences in stress responses may influence the behavioral symptoms of psychiatric disorders that are more often diagnosed in one sex compared with another. The authors conclude with a brief discussion of the implications of this new perspective on treatment approaches and encourage further inquiry into the importance of sex-based differences in the behavioral manifestation of some psychiatric illnesses.
MeSH terms
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Adrenocorticotropic Hormone / metabolism
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Aggression / psychology
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Attention Deficit Disorder with Hyperactivity / immunology
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Attention Deficit Disorder with Hyperactivity / metabolism
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Attention Deficit Disorder with Hyperactivity / physiopathology
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Autonomic Nervous System / immunology
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Autonomic Nervous System / metabolism
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Autonomic Nervous System / physiopathology
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Cytokines / immunology
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Cytokines / metabolism
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Depressive Disorder, Major / immunology
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Depressive Disorder, Major / metabolism
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Depressive Disorder, Major / physiopathology
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Estrogens / metabolism
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Female
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Humans
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Hydrocortisone / metabolism
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Hypothalamo-Hypophyseal System / immunology
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Hypothalamo-Hypophyseal System / metabolism
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Hypothalamo-Hypophyseal System / physiopathology
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Life Change Events*
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Male
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Mental Disorders* / immunology
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Mental Disorders* / metabolism
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Mental Disorders* / physiopathology
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Oxytocin / metabolism
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Pituitary-Adrenal System / immunology
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Pituitary-Adrenal System / metabolism
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Pituitary-Adrenal System / physiopathology
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Sex Factors
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Sleep Wake Disorders / etiology
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Substance-Related Disorders / etiology
Substances
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Cytokines
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Estrogens
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Oxytocin
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Adrenocorticotropic Hormone
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Hydrocortisone