Abstract
Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiates the signaling cascade that leads to the activation of nuclear factor-kappa B and mitogen-activated protein kinases. Analysis of MyD88-deficient mice revealed its essential role in TLR/IL-1R signaling as well as in both the innate and the adaptive immune response.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Antigens, Differentiation / immunology*
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Drosophila Proteins*
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Humans
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Membrane Glycoproteins / immunology*
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Mice
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Myeloid Differentiation Factor 88
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Receptors, Cell Surface / immunology*
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Receptors, Immunologic / immunology*
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Receptors, Interleukin-1 / immunology*
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Signal Transduction / immunology*
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Toll-Like Receptors
Substances
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Adaptor Proteins, Signal Transducing
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Antigens, Differentiation
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Drosophila Proteins
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MYD88 protein, human
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Membrane Glycoproteins
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Myd88 protein, mouse
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Myeloid Differentiation Factor 88
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Receptors, Cell Surface
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Receptors, Immunologic
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Receptors, Interleukin-1
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Toll-Like Receptors