Abstract
The universal stress protein A (UspA) superfamily encompasses an ancient and conserved group of proteins that are found in bacteria, Archea, fungi, flies and plants. The Escherichia coli UspA is produced in response to a large number of different environmental onslaughts and UspA is one of the most abundant proteins in growth-arrested cells. Although insights into the regulation of the E. coli uspA gene have been gained, the exact roles of the Usp proteins and Usp domains remain enigmatic; they appear, in some cases, to be linked to resistance to DNA-damaging agents and to respiratory uncouplers.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Bacterial Proteins / biosynthesis
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics*
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Bacterial Proteins / physiology*
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Biological Factors / classification
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Biological Factors / metabolism
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Escherichia coli Proteins / biosynthesis
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Escherichia coli Proteins / chemistry
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Escherichia coli Proteins / genetics*
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Escherichia coli Proteins / physiology*
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Gene Expression Regulation, Bacterial
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Heat-Shock Proteins / biosynthesis
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Heat-Shock Proteins / chemistry
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Heat-Shock Proteins / genetics*
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Heat-Shock Proteins / physiology*
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Models, Genetic
Substances
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Bacterial Proteins
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Biological Factors
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Escherichia coli Proteins
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Heat-Shock Proteins
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universal stress protein A, Bacteria