Abstract
CART peptide produces behavioral effects when injected into the VTA or nucleus accumbens. In the VTA, the peptide behaves like an endogenous psychostimulant and produces increased locomotor activity and conditioned place preference. Since this is blocked by dopamine receptor blockers, it presumably involves release of dopamine. But in the nucleus accumbens, CART peptide reduces the locomotor-increasing effects of cocaine. This suggests that the peptide is an interesting target for medications development.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Central Nervous System Stimulants / pharmacology*
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Dopamine / metabolism*
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Dopamine Uptake Inhibitors / administration & dosage
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Dopamine Uptake Inhibitors / pharmacology*
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Limbic System / drug effects
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Limbic System / metabolism*
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Motor Activity / drug effects
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / physiology*
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Peptide Fragments / administration & dosage
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Peptide Fragments / pharmacology*
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Ventral Tegmental Area / drug effects
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Ventral Tegmental Area / metabolism
Substances
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Central Nervous System Stimulants
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Dopamine Uptake Inhibitors
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Nerve Tissue Proteins
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Peptide Fragments
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cocaine- and amphetamine-regulated transcript protein
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Dopamine