Abstract
The determination of the crystal structure of human phosphopantothenoylcysteine synthetase completes our knowledge of the enzyme structures involved in all steps of coenzyme A biosynthesis. This structure provides insight into the differences between bacterial and mammalian forms of the enzyme and may guide the structure-based development of novel antibacterial compounds.
Publication types
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Comparative Study
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Comment
MeSH terms
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Coenzyme A / biosynthesis*
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Crystallography, X-Ray
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Dimerization
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Escherichia coli / enzymology
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Humans
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Peptide Synthases / chemistry*
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Peptide Synthases / genetics
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Protein Structure, Quaternary
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Protein Structure, Secondary
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Protein Structure, Tertiary
Substances
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Peptide Synthases
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phosphopantothenoyl-cysteine synthetase
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Coenzyme A