Abstract
A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity: sperm receptors Zp2 and Zp3, betaglycan (also called TGF-beta type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-beta receptor complex.
MeSH terms
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Amino Acid Sequence
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Animals
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Cricetinae
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Dogs
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Egg Proteins*
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Female
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Glycoproteins / chemistry*
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Glycoproteins / genetics
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Humans
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Male
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Membrane Glycoproteins*
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Membrane Proteins / chemistry
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Mice
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Molecular Sequence Data
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Protein Conformation
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Proteoglycans / chemistry
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Rats
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Receptors, Cell Surface / chemistry*
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Receptors, Cell Surface / genetics
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Receptors, Transforming Growth Factor beta
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Sequence Alignment
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Sequence Homology, Nucleic Acid
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Software
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Spermatozoa / chemistry*
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Structure-Activity Relationship
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Transforming Growth Factor beta / chemistry*
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Transforming Growth Factor beta / genetics
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Zona Pellucida Glycoproteins
Substances
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Egg Proteins
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Glycoproteins
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Membrane Glycoproteins
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Membrane Proteins
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Proteoglycans
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Receptors, Cell Surface
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Receptors, Transforming Growth Factor beta
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Transforming Growth Factor beta
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ZP2 protein, human
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ZP3 protein, human
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Zona Pellucida Glycoproteins
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Zp2 protein, mouse
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Zp3 protein, mouse
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betaglycan