Abstract
The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila. Loss-of-function brm mutations suppress mutations in Polycomb, a repressor of homeotic genes, and cause developmental defects similar to those arising from insufficient expression of the homeotic genes of the Antennapedia and Bithorax complexes. The brm gene encodes a 1638 residue protein that is similar to SNF2/SWI2, a protein involved in transcriptional activation in yeast, suggesting possible models for the role of brm in the transcriptional activation of homeotic genes. In addition, both brm and SNF2 contain a 77 amino acid motif that is found in other Drosophila, yeast, and human regulatory proteins and may be characteristic of a new family of regulatory proteins.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine Triphosphatases
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Cloning, Molecular
-
DNA-Binding Proteins / genetics
-
Drosophila / genetics*
-
Gene Library
-
Genes
-
Genes, Homeobox*
-
Genes, Regulator*
-
Molecular Sequence Data
-
Morphogenesis / genetics
-
Nuclear Proteins*
-
Saccharomyces cerevisiae / genetics*
-
Saccharomyces cerevisiae Proteins
-
Sequence Alignment
-
Trans-Activators / chemistry
-
Trans-Activators / genetics*
-
Transcription Factors / genetics
-
Transcription, Genetic / genetics
Substances
-
DNA-Binding Proteins
-
Nuclear Proteins
-
Saccharomyces cerevisiae Proteins
-
Trans-Activators
-
Transcription Factors
-
Adenosine Triphosphatases
-
SNF2 protein, S cerevisiae
Associated data
-
GENBANK/M84159
-
GENBANK/M84160
-
GENBANK/M85049
-
GENBANK/S72766
-
GENBANK/S72767
-
GENBANK/S72768
-
GENBANK/S72769
-
GENBANK/S72771
-
GENBANK/S82271
-
GENBANK/X63098