Abstract
The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas have anti-tumor activities.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Angelica / chemistry*
-
Animals
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Benzopyrans / chemistry
-
Benzopyrans / isolation & purification*
-
Benzopyrans / pharmacology*
-
Butyrates / chemistry
-
Butyrates / isolation & purification*
-
Butyrates / pharmacology*
-
Cell Line, Tumor / transplantation
-
Fluorouracil / administration & dosage
-
Fluorouracil / pharmacokinetics
-
Fluorouracil / therapeutic use
-
Injections, Intraperitoneal
-
Korea
-
Male
-
Medicine, East Asian Traditional
-
Mice
-
Mice, Inbred ICR
-
Neoplasm Transplantation / pathology
-
Neoplasms / drug therapy
-
Neoplasms / etiology
-
Neoplasms / pathology
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Roots / chemistry
-
Sarcoma 180 / drug therapy
-
Sarcoma 180 / pathology
-
Survival Rate
Substances
-
Antineoplastic Agents, Phytogenic
-
Benzopyrans
-
Butyrates
-
Plant Extracts
-
decursin
-
Fluorouracil