Abstract
A previously undetected domain, named CW for its conserved cysteine and tryptophan residues, appears to be a four-cysteine zinc-finger motif found exclusively in vertebrates, vertebrate-infecting parasites and higher plants. Of the twelve distinct nuclear protein families that comprise the CW domain-containing superfamily, only the microrchida (MORC) family has begun to be characterized. However, several families contain other domains suggesting a relationship between the CW domain and either chromatin methylation status or early embryonic development.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Chromatin / genetics
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Chromatin / metabolism
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Conserved Sequence
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Cysteine / chemistry
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Humans
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Molecular Sequence Data
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Parasites / genetics*
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Parasites / metabolism
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Plant Proteins / genetics
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Plants / genetics*
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Plants / metabolism
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Protein Structure, Tertiary
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Sequence Homology, Amino Acid
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Tryptophan / chemistry
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Vertebrates / genetics*
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Vertebrates / metabolism
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Vertebrates / parasitology
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Zinc Fingers / genetics*
Substances
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Chromatin
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Plant Proteins
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Tryptophan
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Cysteine