The effect of repetitive transcranial magnetic stimulation on long-term potentiation in rat hippocampus depends on stimulus intensity

Brain Res. 2003 Dec 12;993(1-2):222-6. doi: 10.1016/j.brainres.2003.09.009.

Abstract

We investigated the effect of repetitive transcranial magnetic stimulation (rTMS) on long-term potentiation (LTP) in the rat hippocampus. Rats were magnetically stimulated at a rate of 1000 pulses/day for 7 days by a round coil, in which the peak magnetic fields at the center of the coil were 0.75 and 1.00 T. LTP enhancement was observed only in the 0.75-T rTMS group, while no change was observed in the 1.00-T rTMS group. These results suggest that the effect of rTMS on LTP depends on the stimulus intensity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Radiation*
  • Electric Stimulation / methods*
  • Hippocampus / anatomy & histology
  • Hippocampus / physiology
  • Hippocampus / radiation effects*
  • In Vitro Techniques
  • Long-Term Potentiation / physiology
  • Long-Term Potentiation / radiation effects*
  • Male
  • Rats
  • Rats, Wistar
  • Time Factors
  • Transcranial Magnetic Stimulation*