14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins

A Aitken; D B Collinge; B P van Heusden; T Isobe; P H Roseboom; G Rosenfeld; J Soll

doi:10.1016/0968-0004(92)90339-b

14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins

Trends Biochem Sci. 1992 Dec;17(12):498-501. doi: 10.1016/0968-0004(92)90339-b.

Authors

A Aitken¹, D B Collinge, B P van Heusden, T Isobe, P H Roseboom, G Rosenfeld, J Soll

Affiliation

¹ Laboratory of Protein Structure, National Institute for Medical Research, Mill Hill, London, UK.

PMID: 1471260
DOI: 10.1016/0968-0004(92)90339-b

Abstract

A family of proteins known as 14-3-3 is currently receiving increased attention by investigators studying a broad range of biological systems, including plants and invertebrates. The outstanding feature of this family is the extraordinarily high sequence conservation observed. Current thinking indicates that these proteins may function as regulators in signal transduction/phosphorylation mechanisms.

Publication types

Review

MeSH terms

14-3-3 Proteins
Amino Acid Sequence
Animals
Conserved Sequence
Eukaryotic Cells / physiology*
Humans
Molecular Sequence Data
Nerve Tissue Proteins / chemistry
Nerve Tissue Proteins / physiology*
Phosphorylation
Plants
Protein Kinase C / antagonists & inhibitors*
Signal Transduction
Tyrosine 3-Monooxygenase*

Substances

14-3-3 Proteins
Nerve Tissue Proteins
Tyrosine 3-Monooxygenase
Protein Kinase C