Intratumoral hypoxia, radiation resistance, and HIF-1

Gregg L Semenza

doi:10.1016/s1535-6108(04)00118-7

Intratumoral hypoxia, radiation resistance, and HIF-1

Cancer Cell. 2004 May;5(5):405-6. doi: 10.1016/s1535-6108(04)00118-7.

Author

Gregg L Semenza¹

Affiliation

¹ Program in Vascular Cell Engineering, The Johns Hopkins University School of Medicine, 733 North Broadway, Suite 671, Baltimore, MD 21205, USA. gsemenza@jhmi.edu

PMID: 15144945
DOI: 10.1016/s1535-6108(04)00118-7

Abstract

Failure to achieve complete remission after radiation therapy is a predictor of patient mortality, and hypoxic cancer cells are more likely to survive radiation therapy. Recent studies have shown that radiation-induced endothelial cell death results in secondary tumor cell killing. In this issue of Cancer Cell, now provide evidence that radiation induces HIF-1-mediated expression of VEGF and bFGF in tumor cells, which promotes endothelial cell survival.

Publication types

Comment
Editorial

MeSH terms

Animals
Cell Hypoxia*
Cell Survival
DNA-Binding Proteins / metabolism*
Endothelium, Vascular / radiation effects
Fibroblast Growth Factor 2 / metabolism
Humans
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Neoplasms / blood supply
Neoplasms / metabolism
Neoplasms / radiotherapy*
Neovascularization, Pathologic / metabolism
Nuclear Proteins / metabolism*
Radiation Tolerance*
Transcription Factors*
Vascular Endothelial Growth Factor A / metabolism

Substances

DNA-Binding Proteins
HIF1A protein, human
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Nuclear Proteins
Transcription Factors
Vascular Endothelial Growth Factor A
Fibroblast Growth Factor 2